Arylamine N‐acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
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منابع مشابه
Arylamine N-acetyltransferases: from drug metabolism and pharmacogenetics to drug discovery
Arylamine N-acetyltransferases (NATs) are polymorphic drug-metabolizing enzymes, acetylating arylamine carcinogens and drugs including hydralazine and sulphonamides. The slow NAT phenotype increases susceptibility to hydralazine and isoniazid toxicity and to occupational bladder cancer. The two polymorphic human NAT loci show linkage disequilibrium. All mammalian Nat genes have an intronless op...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2014
ISSN: 0007-1188,1476-5381
DOI: 10.1111/bph.12598